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The reduced cholesterol saturation permits the gradual solubilization of cholesterol from gallstones, resulting in their eventual dissolution.
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Dyspepsia, epigastric pain, right hypochondriacal pain and other symptoms of biliary and gallstone disease respond, often very rapidly, in about 75 to 85% of patients treated with ursodeoxycholic acid.
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My husband had very high cholestrol in his blood Dr Clark said that was because of these stones blocking the way out the colon and it backs up into the bloodstream.
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The cytoprotective effect is based on the ability of ursodeoxycholic acid incorporated into the lipid layer of the cell membrane, which leads to stabilization of the cell membrane and improve its protective properties.
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Inhibitory effects of ursodeoxycholic acid on N-methylnitrosourea-induced colon carcinogenesis and colonic mucosal telomerase activity in F344 rats.
The onset of these effects may be delayed for up to two months post-treatment; in several cases the course of the reactions has been protracted and lasted for some months.
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UDCA has no significant maternal adverse effects.
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The purpose of this study was to determine the bioequivalence of four preparations of ursodeoxycholic acid (UDCA), which is currently the drug of choice for dissolving of cholesterol gallstones, and the probable drug of choice for chronic cholestatic liver disease, especially primary biliary cirrhosis.
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In PBC, ursodiol treatment has been shown to improve liver biochemistry and delay disease progression and time to liver transplantation.
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Based on a simple correlation with the gallstone dissolution rate, small size, radiolucency of gallstone, and preserved gallbladder function have been listed as indication criteria for UDCA therapy.
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Lithotripsy was more effective for solitary than multiple stones, radiolucent than slightly calcified stones, and smaller than larger stones.
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